Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Many retinal diseases lead to the loss of retinal neurons and cause visual impairment. The
adult mammalian retina has little capacity for regeneration. By contrast, teleost fish …

Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this
regenerative response are Müller glia that respond to retinal injury by undergoing a …

For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Radial glia is a cell type traditionally associated with the develo** nervous system,
particularly with the formation of cortical layers in the mammalian brain. Nonetheless, some …

Methanol-induced optic neuropathy (Me-ION) is a serious condition that may result in long-
term or irreversible visual impairment or even blindness secondary to damage and loss of …

Müller glial cells are the source of retinal regeneration in fish and birds; although this
process is efficient in fish, it is less so in birds and very limited in mammals. It has been …

In all vertebrate species studied thus far, the adult central nervous system harbors neural
stem cells that sustain constitutive neurogenesis, as well as latent neural progenitors that …

Over the past two decades, evidence has accumulated that neurogenesis can occur in both
the juvenile and adult mammalian hypothalamus. Levels of hypothalamic neurogenesis can …