In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Abstract mRNA medicine is a new and rapidly develo** field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

The number of sequenced viral genomes has surged recently, presenting an opportunity to
understand viral diversity and uncover unknown regulatory mechanisms. Here, we …

Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …

Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins.
However, the practical use of synthetic mRNAs has been restricted by their low cellular …

Background & Aims Chronic coinfection with HBV and HDV leads to the most aggressive
form of chronic viral hepatitis. Herein, we aimed to elucidate the molecular mechanisms …

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of
hospitalizations and hundreds of deaths within the United States in recent years. There is no …

Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis
B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels …

Abstract Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal
uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single …