21st century natural product research and drug development and traditional medicines
Covering: 1987 to 2013 Natural products and related structures are essential sources of new
pharmaceuticals, because of the immense variety of functionally relevant secondary …
pharmaceuticals, because of the immense variety of functionally relevant secondary …
Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
Chronic obstructive pulmonary disease (COPD) is a complex disease at the clinical, cellular,
and molecular levels. However, its diagnosis, assessment, and therapeutic management are …
and molecular levels. However, its diagnosis, assessment, and therapeutic management are …
The new holism: P4 systems medicine and the medicalization of health and life itself
H Vogt, B Hofmann, L Getz - Medicine, Health Care and Philosophy, 2016 - Springer
The emerging concept of systems medicine (or 'P4 medicine'—predictive, preventive,
personalized and participatory) is at the vanguard of the post-genomic movement towards …
personalized and participatory) is at the vanguard of the post-genomic movement towards …
Predictive, preventive, personalized and participatory medicine: back to the future
The pioneering work of Jean Dausset on the HLA system established several principles that
were later reflected in the Human Genome Project and contributed to the foundations of …
were later reflected in the Human Genome Project and contributed to the foundations of …
Systems biology approaches to adverse drug effects: the example of cardio-oncology
SA Brown, N Sandhu, J Herrmann - Nature Reviews Clinical Oncology, 2015 - nature.com
Increased awareness of the cardiovascular toxic effects of chemotherapy has led to the
emergence of cardio-oncology (or onco-cardiology), which focuses on screening, monitoring …
emergence of cardio-oncology (or onco-cardiology), which focuses on screening, monitoring …
Applying systems biology to biomedical research and health care: a précising definition of systems medicine
S Schleidgen, S Fernau, H Fleischer… - BMC health services …, 2017 - Springer
Background Systems medicine has become a key word in biomedical research. Although it
is often referred to as P4-(predictive, preventive, personalized and participatory)-medicine, it …
is often referred to as P4-(predictive, preventive, personalized and participatory)-medicine, it …
An early stage researcher's primer on systems medicine terminology
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary
field that considers the human body as a system, composed of multiple parts and of complex …
field that considers the human body as a system, composed of multiple parts and of complex …
Tools for protein-protein interaction network analysis in cancer research
As cancer is a complex disease, the representation of a malignant cell as a protein-protein
interaction network (PPIN) and its subsequent analysis can provide insight into the …
interaction network (PPIN) and its subsequent analysis can provide insight into the …
Network medicine: linking disorders
RM Piro - Human genetics, 2012 - Springer
The molecular events underlying many human hereditary disorders remain to be discovered
despite the significant advances made in molecular biology and genetics in the past years …
despite the significant advances made in molecular biology and genetics in the past years …
Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine
M Darrason - Synthese, 2018 - Springer
Medical explanations have often been thought on the model of biological ones and are
frequently defined as mechanistic explanations of a biological dysfunction. In this paper, I …
frequently defined as mechanistic explanations of a biological dysfunction. In this paper, I …