This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

The brain continuously adapts its processing machinery to behavioural demands. To
achieve this, it rapidly modulates the operating mode of cortical circuits, controlling the way …

The mammalian basal forebrain (BF) has important roles in controlling sleep and
wakefulness, but the underlying neural circuit remains poorly understood. We examined the …

Switches between different behavioral states of the animal are associated with prominent
changes in global brain activity, between sleep and wakefulness or from inattentive to …

Basal forebrain cholinergic neurons constitute a major neuromodulatory system implicated
in normal cognition and neurodegenerative dementias. Cholinergic projections densely …

Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …

Wakefulness, along with fast cortical rhythms and associated cognition, depend on the basal
forebrain (BF). BF cholinergic cell loss in dementia and the sedative effect of anti-cholinergic …

Brain systems communicate by means of neuronal oscillations at multiple temporal and
spatial scales. In anesthetized rats, we find that neocortical" slow" oscillation engages …

Based on recent molecular genetics, as well as functional and quantitative anatomical
studies, the basal forebrain (BF) cholinergic projections, once viewed as a diffuse system …

Cortical gamma band oscillations (GBO, 30–80 Hz, typically∼ 40 Hz) are involved in higher
cognitive functions such as feature binding, attention, and working memory. GBO …