Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

Post-transcriptional cleavage of RNA molecules to generate smaller fragments is a
widespread mechanism that enlarges the structural and functional complexity of cellular …

Publisher Summary This chapter focuses on recent biochemical and biophysical studies that
examine the nucleic acid chaperone function of HIV‐1 nucleocapsid protein (NC) and its …

Retroviruses are a family of widespread small animal viruses about 110 nm in diameter,
composed of an inner core surrounded by an outer envelope formed of a lipid bilayer of …

Direct sequencing of human mitochondrial tRNALys shows the absence of editing and the
occurrence of six modified nucleotides (m1A9, m2G10, Ψ27, Ψ28 and hypermodified …

Both retroviruses and long terminal repeat (LTR) retrotransposons use cellular tRNAs as
primers for reverse transcription during their replication cycles. In retroviruses, primer tRNA …

Publisher Summary This chapter deals with the structure and function of the leader transcript
of human immunodeficiency virus (HIV-1) and HIV-2. Most of the RNA signals encoded by …

Abstract Since the Human Immunodeficiency Virus Type 1 (HIV‐1) was identified as the
etiologic agent of the Acquired Immune Deficiency Syndrome (AIDS), the HIV‐1 reverse …

The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN) is essential for
integration of the viral DNA into host cell chromosomes. Since IN is expressed and …

In this study we demonstrate that the HIV-1 leader RNA exists in two alternative
conformations, a branched structure consisting of several well-known hairpin motifs and a …