Parasitic nematodes infect almost all forms of life. In the human context, parasites are one of
the major causative factors for physical and intellectual growth retardation in the develo** …

Background The antihelminthic drug praziquantel has been used as the drug of choice for
treating schistosome infection for more than 40 years. Although some epidemiological …

Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

Mass drug administration with praziquantel (PZQ) monotherapy is considered the mainstay
for control and elimination of the parasites causing schistosomiasis in humans. This drug …

Praziquantel (PZQ) is the drug of choice for treating infection with worms from the genus
Schistosoma. The drug is effective, cheap and has few side effects. However, despite its use …

Do mutations required for adaptation occur de novo, or are they segregating within
populations as standing genetic variation? This question is key to understanding adaptive …

The G× E concept, in which genotype× environment interactions bring about the phenotype,
is widely used to describe biological phenomena. We propose to extend the initial notion of …

Schistosoma mansoni, a snail‐borne, blood fluke that infects humans, was introduced into
the Americas from Africa during the Trans‐Atlantic slave trade. As this parasite shows strong …

Intestinal helminths are extremely widespread and highly prevalent infections of humans,
particularly in rural and poor urban areas of low and middle-income countries. These …

Human schistosomiasis is a disease which globally affects over 229 million people. Three
major species affecting humans are Schistosoma mansoni, S. haematobium and S …