Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis
Y ** therapeutic agents with potent antitumor activity that spare normal tissues
remains a significant challenge. Clonal loss of heterozygosity (LOH) is a widespread and …
remains a significant challenge. Clonal loss of heterozygosity (LOH) is a widespread and …
New perspectives on the importance of cell-free DNA biology
Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …
Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules
The analysis of cell-free DNA (cfDNA) from plasma offers great promise for the earlier
detection of cancer. At present, changes in DNA sequence, methylation, or copy number are …
detection of cancer. At present, changes in DNA sequence, methylation, or copy number are …
Machine learning to detect the SINEs of cancer
We previously described an approach called RealSeqS to evaluate aneuploidy in plasma
cell-free DNA through the amplification of~ 350,000 repeated elements with a single primer …
cell-free DNA through the amplification of~ 350,000 repeated elements with a single primer …