Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

H Zhang, X Yue, Z Chen, C Liu, W Wu, N Zhang, Z Liu… - Molecular Cancer, 2023 - Springer
Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Biomarker-driven personalization of neoadjuvant immunotherapy in melanoma

LL Hoeijmakers, ILM Reijers, CU Blank - Cancer Discovery, 2023 - AACR
The introduction of immunotherapy has ushered in a new era of anticancer therapy for many
cancer types including melanoma. Given the increasing development of novel compounds …

The elusive coreceptors for the SARS-CoV-2 spike protein

RL Berkowitz, DA Ostrov - Viruses, 2022 - mdpi.com
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein
interacts with host coreceptors that participate in viral entry. Resolving the identity of …

The m5C methyltransferase NSUN2 promotes codon‐dependent oncogenic translation by stabilising tRNA in anaplastic thyroid cancer

P Li, W Wang, R Zhou, Y Ding… - Clinical and Translational …, 2023 - Wiley Online Library
Background Translation dysregulation plays a crucial role in tumourigenesis and cancer
progression. Oncogenic translation relies on the stability and availability of tRNAs for protein …

Defining the emergence of new immunotherapy approaches in breast cancer: role of myeloid-derived suppressor cells

ML Sánchez-León, C Jiménez-Cortegana… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC) continues to be the most diagnosed tumor in women and a very
heterogeneous disease both inter-and intratumoral, mainly given by the variety of molecular …

Dissecting the Molecular Basis of Host Leucine-Rich Repeat Containing 15 Mediated Interaction with Receptor Binding Domain of SARS-CoV-2 Spike Protein: A …

S Mishra, M Sharma, MK Singh, S Pati… - The Journal of Physical …, 2023 - ACS Publications
The detection of leucine-rich repeat containing 15 (LRRC15) as a connecting link with
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the possibility …

Global transcriptomic network analysis of the crosstalk between microbiota and cancer-related cells in the oral-gut-lung axis

BA Otálora-Otálora, C Payán-Gómez… - Frontiers in Cellular …, 2024 - frontiersin.org
Background The diagnosis and treatment of lung, colon, and gastric cancer through the
histologic characteristics and genomic biomarkers have not had a strong impact on the …

The role of vimentin in human corneal fibroblast spreading and myofibroblast transformation

M Miron-Mendoza, K Poole, S DiCesare, E Nakahara… - Cells, 2024 - mdpi.com
Vimentin has been reported to play diverse roles in cell processes such as spreading,
migration, cell–matrix adhesion, and fibrotic transformation. Here, we assess how vimentin …

[HTML][HTML] Identification of leucine-rich repeat-containing protein 59 (LRRC59) located in the endoplasmic reticulum as a novel prognostic factor for urothelial carcinoma

L Pei, Q Zhu, X Zhuang, H Ruan, Z Zhao, H Qin… - Translational …, 2022 - Elsevier
Background Urothelial carcinoma (UC) is one of the most common cancers worldwide. The
biological heterogeneity of UCs causes considerable difficulties in predicting treatment …

Forces exerted and transduced by cancer‐associated fibroblasts during cancer progression

ME Bates, S Libring, CA Reinhart‐King - Biology of the Cell, 2023 - Wiley Online Library
Although it is well‐known that cancer‐associated fibroblasts (CAFs) play a key role in
regulating tumor progression, the effects of mechanical tissue changes on CAFs are …