Cells don't simply separate at cytokinesis. While furrow contraction critically relies on myosin-
II and F-actin, post-furrowing steps are less understood but involve the constriction of …

Cerebral cavernous malformations (CCM) are manifested by microvascular lesions
characterized by leaky endothelial cells with minimal intervening parenchyma …

The apical inflammatory cytokine TNF regulates numerous important biological processes
including inflammation and cell death, and drives inflammatory diseases. TNF secretion …

Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial
CCM is caused by genetic mutations in KRIT1, CCM2, or PDCD10. Disease onset is earlier …

Endosomal trafficking plays an important role in regulating plant growth and development
both at optimal and stressed conditions. Cold stress response in Arabidopsis root is directly …

The purpose of this study was to determine important genes, functions, and networks
contributing to the pathobiology of cerebral cavernous malformation (CCM) from …

Striatin-interacting protein 1 (Strip1) is a core component of the striatin interacting
phosphatase and kinase (STRIPAK) complex, which is involved in embryogenesis and …

BACKGROUND RAB GTPases constitute the largest family of small GTPases and are found
in all eukaryotes. RAB GTPases regulate components of the endomembrane system, the …

The canonical eukaryotic cell cycle ends with cytokinesis, which physically divides the
mother cell in two and allows the cycle to resume in the newly individualized daughter cells …

Eukaryotic striatin forms striatin-interacting phosphatase and kinase (STRIPAK) complexes
that control many cellular processes including development, cellular transport, signal …