Annotators of the human genome are increasingly exploiting comparisons with genomes at
both the distal and proximal evolutionary edges of the vertebrate tree. Despite the sequence …

In addition to protein coding sequence, the human genome contains a significant amount of
regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

Sequence conservation has been used to find genes and to pinpoint functional non-coding
sequences such as transcriptional regulatory elements. In this article, we analysed the …

Background Early life stages are generally most sensitive to toxic effects. Our knowledge on
the action of manmade chemicals on the develo** vertebrate embryo is, however, rather …

Objective To identify the components of conditioned medium obtained from intervertebral
disc nucleus pulposus–derived canine notochord cells, and to evaluate the capacity of such …

Hypocretins/orexins are neuropeptides involved in the regulation of sleep and energy
balance in mammals. Conservation of gene sequence, hypothalamic localization of cell …

Caudal fin regeneration is characterized by a proliferation boost in the mesenchymal
blastema that is controlled precisely in time and space. This allows a gradual and robust …

Fish–mammal genomic comparisons have proved powerful in identifying conserved
noncoding elements likely to be cis-regulatory in nature, and the majority of those tested in …

In zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)
is expressed in organiser regions such as the embryonic midline and the zona limitans …