Neuroglobin: From structure to function in health and disease

P Ascenzi, A di Masi, L Leboffe, M Fiocchetti… - Molecular aspects of …, 2016 - Elsevier
In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Cross‐talk between (Hydrogen) Sulfite and metalloproteins: impact on human health

BK Maiti - Chemistry–A European Journal, 2022 - Wiley Online Library
Sulfite is a potent toxic substance causing harm to multi‐organ in human. Despite toxicity, it
is widely used as preservative, anti‐browning and anti‐oxidant in foods, beverages, and …

Neuroglobin, clues to function and mechanism

C Exertier, LC Montemiglio, I Freda, E Gugole… - Molecular Aspects of …, 2022 - Elsevier
Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family
that diverged early in evolution. Sequence conservation and presence in nervous cells of …

14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide

T Jayaraman, J Tejero, BB Chen, AB Blood… - Journal of Biological …, 2011 - jbc.org
Neuroglobin protects neurons from hypoxia in vitro and in vivo; however, the underlying
mechanisms for this effect remain poorly understood. Most of the neuroglobin is present in a …

NO and heme proteins: Cross-talk between heme and cysteine residues

C Verde, D Giordano, S Bruno - Antioxidants, 2023 - mdpi.com
Heme proteins are a diverse group that includes several unrelated families. Their biological
function is mainly associated with the reactivity of the heme group, which—among several …

[HTML][HTML] Structural and (pseudo-) enzymatic properties of neuroglobin: its possible role in neuroprotection

G De Simone, D Sbardella, F Oddone, A Pesce… - Cells, 2021 - mdpi.com
Neuroglobin (Ngb), the third member of the globin family, was discovered in human and
murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and …

Immobilization of proteins in silica gel: biochemical and biophysical properties

L Ronda, S Bruno, B Campanini… - Current Organic …, 2015 - ingentaconnect.com
The development of silica-based sol-gel techniques compatible with the retention of protein
structure and function started more than 20 years ago, mainly for the design of …

Neuroglobin expression in the brain: a story of tissue homeostasis preservation

ZP Van Acker, E Luyckx, S Dewilde - Molecular neurobiology, 2019 - Springer
After its discovery in 2000, the notion grew that neuroglobin, a neuronal specific heme
protein, is involved in cytoprotection. To date, neuroglobin levels have been positively …

Neuroglobin, a factor playing for nerve cell survival

D Guidolin, C Tortorella, M Marcoli, G Maura… - International journal of …, 2016 - mdpi.com
Cell death represents the final outcome of several pathological conditions of the central
nervous system and available evidence suggests that in both acute injuries and …

Protein dynamics and ligand migration interplay as studied by computer simulation

P Arroyo-Mañez, DE Bikiel, L Boechi, L Capece… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Since proteins are dynamic systems in living organisms, the employment of methodologies
contemplating this crucial characteristic results fundamental to allow revealing several …