Bacterial cells require DNA segregation machinery to properly distribute a genome to both
daughter cells upon division. The most common system involved in chromosome and …

Streptomyces are soil bacteria with complex life cycle. During sporulation Streptomyces
linear chromosomes become highly compacted so that the genetic material fits within limited …

Lysine lactylation is a newly discovered protein post-translational modification that plays
regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It …

Bacteria of the genus Streptomyces have a linear chromosome, with a core region and two
'arms'. During their complex life cycle, these bacteria develop multi-genomic hyphae that …

Lysine acylations are reversible and ubiquitous post-translational modifications that play
critical roles in regulating multiple cellular processes. In the current study, highly abundant …

Polyketides are one of the largest categories of secondary metabolites, and their
biosynthesis is initiated by polyketide synthases (PKSs) using coenzyme A esters of short …

Sirtuins are a group of NAD+-dependent deacylases that conserved in three domains of life
and comprehensively involved in the regulation of gene transcription, chromosome …

Bacteria employ a myriad of regulatory mechanisms to adapt to the continuously changing
environments that they face. They can, for example, use post-translational modifications …

Since the discovery of the sirtuin family founding member (ie, the yeast silent information
regulator 2 (sir2) protein) in 2000, more and more sirtuin proteins have been identified and …

The segregation of bacterial chromosomes is widely mediated by partitioning proteins
(ParAB). While ParB binds DNA specifically by recognising short, palindromic sequences …