This personal recollection looks at the evolution of ideas about the dynamics of the blood
oxygenation level dependent (BOLD) signal, with an emphasis on the balloon model. From …

Functional magnetic resonance imaging is widely used to map patterns of brain activation
based on blood oxygenation level dependent (BOLD) signal changes associated with …

The mechanisms that link a transient neural activity to the corresponding increase of
cerebral blood flow (CBF) are termed neurovascular coupling (NVC). They are possibly …

Calibrated blood oxygenation level dependent (BOLD) imaging, a technique used to
measure changes in cerebral O2 metabolism, depends on an accurate model of how the …

In a companion paper (Lorthois et al., Neuroimage, in press), we perform the first simulations
of blood flow in an anatomically accurate large human intra-cortical vascular network …

The idea that astrocytes may be active partners in synaptic information processing has
recently emerged from abundant experimental reports. Because of their spatial proximity to …

Several current functional neuroimaging methods are sensitive to cerebral metabolism and
cerebral blood flow (CBF) rather than the underlying neural activity itself. Empirically, the …

The human brain is possibly the most complex organ in existence. This complexity means
that it is capable of great feats, yet has ensured that it remains surprisingly poorly …

A state-of-the-art integrated model of neurovascular coupling (NVC)(Dormanns et al., 2015b;
Dormanns et al., 2016; Kenny et al., 2018) and the BOLD response (Mathias et al., 2017a; …

Many of the major advances in our understanding of how functional brain imaging signals
relate to neuronal activity over the previous two decades have arisen from physiological …