Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …

Depression is the leading cause of disability worldwide. Recent observations have revealed
an association between mood disorders and alterations of the intestinal microbiota. Here …

Using behavioral, pharmacological, and molecular methods, lots of studies reveal that
depression is closely related to the abnormal neural plasticity processes occurring in the …

Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …

Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

The precise functional role of the hippocampus remains a topic of much debate. The
dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and …