Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Neuronal and astrocyte determinants of critical periods of plasticity
Y Andrade-Talavera, M Pérez-Rodríguez… - Trends in …, 2023 - cell.com
Windows of plasticity allow environmental experiences to produce intense activity-
dependent changes during postnatal development. The reordering and refinement of neural …
dependent changes during postnatal development. The reordering and refinement of neural …
Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
R Falcón-Moya, M Pérez-Rodríguez… - Nature …, 2020 - nature.com
Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1
synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week …
synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week …
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses
I Martínez-Gallego, H Coatl-Cuaya… - Elife, 2024 - elifesciences.org
The entorhinal cortex (EC) connects to the hippocampus sending different information from
cortical areas that is first processed at the dentate gyrus (DG) including spatial, limbic and …
cortical areas that is first processed at the dentate gyrus (DG) including spatial, limbic and …
[HTML][HTML] Metabotropic actions of kainate receptors modulating glutamate release
R Falcón-Moya, A Rodríguez-Moreno - Neuropharmacology, 2021 - Elsevier
Presynaptic kainate (KA) receptors (KARs) modulate GABA and glutamate release in the
central nervous system of mammals. While some of the actions of KARs are ionotropic …
central nervous system of mammals. While some of the actions of KARs are ionotropic …
Treatment of cerebral ischemia through NMDA receptors: metabotropic signaling and future directions
Y Li, X Cheng, X Liu, L Wang, J Ha, Z Gao… - Frontiers in …, 2022 - frontiersin.org
Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is
a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx …
a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx …
NMDA receptors in axons: there's no coincidence
In the textbook view, N‐methyl‐d‐aspartate (NMDA) receptors are postsynaptically located
detectors of coincident activity in Hebbian learning. However, controversial presynaptically …
detectors of coincident activity in Hebbian learning. However, controversial presynaptically …
Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins …
Neurocognitive consequences of blast-induced traumatic brain injury (bTBI) pose significant
concerns for military service members and veterans with the majority of “invisible injury.” …
concerns for military service members and veterans with the majority of “invisible injury.” …
NMDA receptor function in inhibitory neurons
SA Booker, DJA Wyllie - Neuropharmacology, 2021 - Elsevier
N-methyl-d-aspartate receptors (NMDARs) are present in the majority of brain circuits and
play a key role in synaptic information transfer and synaptic plasticity. A key element of many …
play a key role in synaptic information transfer and synaptic plasticity. A key element of many …
[HTML][HTML] Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions
Metamodulation shifted the scenario of the central neuromodulation from a simplified
unimodal model to a multimodal one. It involves different receptors/membrane proteins …
unimodal model to a multimodal one. It involves different receptors/membrane proteins …