Advancements in addressing drug dependence: A review of promising therapeutic strategies and interventions

CR Guida, JM Maia, LFR Ferreira, A Rahdar… - Progress in Neuro …, 2024 - Elsevier
Substance dependence represents a pervasive global concern within the realm of public
health. Presently, it is delineated as a persistent and recurrent neurological disorder …

Neurophysiological mechanisms underlying the differential effect of reward prospect on response selection and inhibition

AH Koyun, AK Stock, C Beste - Scientific Reports, 2023 - nature.com
Reward and cognitive control play crucial roles in sha** goal-directed behavior. Yet, the
behavioral and neural underpinnings of interactive effects of both processes in driving our …

Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour

F Burghoorn, A Scheres, J Monterosso, M Guo… - Cognitive, Affective, & …, 2024 - Springer
People often exhibit intertemporal impatience by choosing immediate small over delayed
larger rewards, which has been implicated across maladaptive behaviours and mental …

Emotional cues reduce Pavlovian interference in feedback-based go and nogo learning

J Vahedi, A Mundorf, C Bellebaum, J Peterburs - Psychological Research, 2024 - Springer
It is easier to execute a response in the promise of a reward and withhold a response in the
promise of a punishment than vice versa, due to a conflict between cue-related Pavlovian …

A systematic review of the cognitive effects of the COMT inhibitor, tolcapone, in adult humans

E Kings, K Ioannidis, JE Grant, SR Chamberlain - CNS spectrums, 2024 - cambridge.org
Objective The catechol-o-methyltransferase (COMT) inhibitor tolcapone constitutes a
potentially useful probe of frontal cortical dopaminergic function. The aim of this systematic …

The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled …

J Malamud, G Lewis, M Moutoussis, L Duffy… - Psychological …, 2024 - cambridge.org
BackgroundSelective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological
treatments for depression and anxiety. However, little is known about how pharmacological …

Transcranial direct-current stimulation enhances Pavlovian tendencies during intermittent loss of control

T Sedlinská, L Bolte, E Melsæter, M Mittner… - Frontiers in …, 2023 - frontiersin.org
Introduction Pavlovian bias is an innate motivational tendency to approach rewards and
remain passive in the face of punishment. The relative reliance on Pavlovian valuation has …

[PDF][PDF] Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

D Geurts, H den Ouden, J Swart, MI Froböse, SJ Fallon… - 2024 - osf.io
Value-based decision-making is regulated by a delicate interplay of instrumental and
Pavlovian controllers. Here we assessed the role of catecholamines in this interplay. We …

Dynamics of Mood and Cognition in Depression and Anxiety: a Computational Approach

J Malamud - 2023 - discovery.ucl.ac.uk
Psychiatric conditions such as depression and anxiety have far-reaching and devastating
effects worldwide. Recent decades have seen a rapid advance in mental health science, in …

[PDF][PDF] Pavlovian Bias is Associated with Symptom Severity in Individuals with Anxious Depression

CM Goldman, N Hakimi, MM Mehta, M Ironside… - researchgate.net
Human decision-making favors approach behavior to gain rewards and avoidance behavior
to prevent punishment. While adaptive in some cases, this Pavlovian bias can also interfere …