Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian
survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

The intestinal epithelial tight junctions (TJs) provide barrier against paracellular permeation
of lumenal antigens. Defects in TJ barrier such as increased levels of pore-forming TJ …

Fibrosis is a pathological process that affects multiple organs and is considered one of the
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …

Colitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges
from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic …

Chronic infection with Helicobacter pylori is the primary risk factor for the development of
gastric cancer. Hindering our ability to comprehend the precise role of autophagy during H …

Blood–brain barrier (BBB) dysfunction causing edema and hemorrhagic transformation is
one of the pathophysiological characteristics of stroke. Protection of BBB integrity has shown …

Abstract Background and Aims Functional loss of the gut epithelium's paracellular tight
junction [TJ] barrier and defective autophagy are factors potentiating inflammatory bowel …

Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …

Autophagy is a conserved catabolic process that controls organelle quality, removes
misfolded or abnormally aggregated proteins and is part of the defense mechanisms against …