Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Macromolecular phase separation is being recognized for its potential importance and
relevance as a driver of spatial organization within cells. Here, we describe a framework …

Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular
condensates,,–. The functions of condensates span many length scales: they modulate …

Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …

Control of the electrochemical environment in living cells is typically attributed to ion
channels. Here, we show that the formation of biomolecular condensates can modulate the …

The most commonly occurring intrinsically disordered proteins (IDPs) are polyampholytes,
which are defined by the duality of low net charge per residue and high fractions of charged …

Highly disordered complexes between oppositely charged intrinsically disordered proteins
present a new paradigm of biomolecular interactions. Here, we investigate the driving forces …

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …