Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
T cell responses to SARS-CoV-2
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …
The current state of the art and future trends in RAS-targeted cancer therapies
Despite being the most frequently altered oncogenic protein in solid tumours, KRAS has
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
[HTML][HTML] Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million …
U Agrawal, S Bedston, C McCowan, J Oke, L Patterson… - The Lancet, 2022 - thelancet.com
Background Current UK vaccination policy is to offer future COVID-19 booster doses to
individuals at high risk of serious illness from COVID-19, but it is still uncertain which groups …
individuals at high risk of serious illness from COVID-19, but it is still uncertain which groups …
Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis …
Background Synthesising evidence on the long-term vaccine effectiveness of COVID-19
vaccines (BNT162b2 [Pfizer–BioNTech], mRNA-1273 [Moderna], ChAdOx1 nCoV-19 …
vaccines (BNT162b2 [Pfizer–BioNTech], mRNA-1273 [Moderna], ChAdOx1 nCoV-19 …
Antibody-mediated neutralization of SARS-CoV-2
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
Association of prior BNT162b2 COVID-19 vaccination with symptomatic SARS-CoV-2 infection in children and adolescents during omicron predominance
KE Fleming-Dutra, A Britton, N Shang, G Derado… - Jama, 2022 - jamanetwork.com
Importance Efficacy of 2 doses of the BNT162b2 COVID-19 vaccine (Pfizer-BioNTech)
against COVID-19 was high in pediatric trials conducted before the SARS-CoV-2 Omicron …
against COVID-19 was high in pediatric trials conducted before the SARS-CoV-2 Omicron …
Association of primary and booster vaccination and prior infection with SARS-CoV-2 infection and severe COVID-19 outcomes
Importance Data about the association of COVID-19 vaccination and prior SARS-CoV-2
infection with risk of SARS-CoV-2 infection and severe COVID-19 outcomes may guide …
infection with risk of SARS-CoV-2 infection and severe COVID-19 outcomes may guide …
T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19
Individuals with primary and pharmacologic B cell deficiencies have high rates of severe
disease and mortality from coronavirus disease 2019 (COVID-19), but the immune …
disease and mortality from coronavirus disease 2019 (COVID-19), but the immune …