Angiotensin II (AngII), the major effector peptide of renin–angiotensin system (RAS), is now
recognized as a growth factor that regulates cell growth and fibrosis, besides being a …

The full repertoire of molecules and mechanisms which lead to cardiac hypertrophy are
poorly understood. Many studies over the last several decades have shown how various …

The emergence of lysosome-targeting chimeras (LYTACs), which represents a promising
strategy for membrane protein degradation based on lysosomal pathways, has attracted …

The NG2 proteoglycan is expressed by microvascular pericytes in newly formed blood
vessels. We have used in vitro and in vivo models to investigate the role of NG2 in cross-talk …

Tetraspanins associate with several transmembrane proteins forming microdomains
involved in intercellular adhesion and migration. Here, we show that endothelial …

Therapeutic targeting of angiogenesis in glioblastoma has yielded mixed outcomes.
Investigation of tumor-associated angiogenesis has focused on the factors that stimulate the …

Profiling gene expression in endothelial cells advances the understanding of normal
vascular physiology and disease processes involving angiogenesis. However, endothelial …

One of the hallmarks of cancer is the ability to activate invasion and metastasis. Cancer
morbidity and mortality are largely related to the spread of the primary, localized tumour to …

Several recent publications have described examples of physical and functional interations
between tetraspanins and specific membrane proteases belonging to the TM-MMP and α …

Abstract The von Hippel-Lindau tumor suppressor gene (VHL) is absent or inactivated in the
VHLcancer syndrome and in most sporadic renal cancers. VHL is requiredfor the assembly …