RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …

Based on recent findings indicating that metabolism might be governed by a limit on the rate
at which cells can dissipate Gibbs energy, in this Perspective, we propose a new …

The transcriptome-wide contributions of Rho-dependent and intrinsic (Rho-independent)
transcription termination mechanisms in bacteria are unclear. By sequencing released …

Nearest neighbor parameters for estimating the folding stability of RNA secondary structures
are in widespread use. For helices, current parameters penalize terminal AU base pairs …

NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus
subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the …

RNA structure regulates bacterial gene expression by several distinct mechanisms via
environmental and cellular stimuli, one of which is temperature. While some genome-wide …

Riboswitches are regulatory noncoding RNAs found in bacteria, fungi and plants, that
modulate gene expressions through structural changes in response to ligand binding …

Ligand-binding RNAs (RNA aptamers) are widespread in the three domains of life, serving
as sensors of metabolites and other small molecules. When aptamers are embedded within …

First believed to be a simple intermediary between the information encoded in
deoxyribonucleic acid and that functionally displayed in proteins, ribonucleic acid (RNA) is …

Mycobacteria encounter a number of environmental changes during infection and respond
using different mechanisms. Small RNA (sRNA) is a post-transcriptionally regulatory system …