Much progress has been made over the last few decades in the identification of new anti-
epileptic drugs (AEDs). However, 30% of epilepsy patients suffer poor seizure control. This …

A major challenge modern society has to face is the increasing need for tissue regeneration
due to degenerative diseases or tumors, but also accidents or warlike conflicts. There is …

Background Novel developmental functions have been attributed to the P2X7 receptor
(P2X7R) including proliferation stimulation and neural differentiation. Mouse embryonic …

Hematopoietic stem cells (HSCs) emerge from aortic endothelium via the endothelial-to-
hematopoietic transition (EHT). The molecular mechanisms that initiate and regulate EHT …

Brain injury generates the release of a multitude of factors including extracellular
nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions …

Mesenchymal stem cells (MSCs) have recently been described to home to brain tumors and
to integrate into the tumor-associated stroma. Understanding the communication between …

Extracellular ATP, related nucleotides and adenosine are among the earliest signaling
molecules, operating in virtually all tissues and cells. Through their specific receptors …

The circadian rhythm orchestrates many cellular functions, such as cell division, cell
migration, metabolism and numerous intracellular biological processes. The physiological …

Metastasis is the worst prognosis predictor in the clinical course of cancer development.
Features of metastatic cancer cells include migratory ability, low degree of differentiation …

There has been tremendous progress in understanding neural stem cell (NSC) biology, with
genetic and cell biological methods identifying sequential gene expression and molecular …