Chikungunya fever

K Bartholomeeusen, M Daniel, DA LaBeaud… - Nature Reviews …, 2023 - nature.com
Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …

The impact of deforestation, urbanization, and changing land use patterns on the ecology of mosquito and tick-borne diseases in Central America

DI Ortiz, M Piche-Ovares, LM Romero-Vega, J Wagman… - Insects, 2021 - mdpi.com
Simple Summary Central America is a region that possesses distinct ecological and
socioeconomic characteristics, making it increasingly vulnerable to vector-borne diseases …

Shifts in receptors during submergence of an encephalitic arbovirus

W Li, JA Plante, CY Lin, H Basu, JS Plung, X Fan… - Nature, 2024 - nature.com
Western equine encephalitis virus (WEEV) is an arthropod-borne virus (arbovirus) that
frequently caused major outbreaks of encephalitis in humans and horses in the early …

New insights into chikungunya virus infection and pathogenesis

V Kril, O Aïqui-Reboul-Paviet, L Briant… - Annual Review of …, 2021 - annualreviews.org
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for
major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the …

Not all mosquitoes are created equal: A synthesis of vector competence experiments reinforces virus associations of Australian mosquitoes

MP Kain, EB Skinner, TS Athni… - PLoS Neglected …, 2022 - journals.plos.org
The globalization of mosquito-borne arboviral diseases has placed more than half of the
human population at risk. Understanding arbovirus ecology, including the role individual …

Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity

A Ghoshal, KH Asressu, MA Hossain… - Journal of Medicinal …, 2024 - ACS Publications
Despite their widespread impact on human health, there are no approved drugs for
combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 …

Early genomic surveillance and phylogeographic analysis of Getah virus, a reemerging arbovirus, in livestock in China

J Zhao, S Dellicour, Z Yan, M Veit, MS Gill… - Journal of …, 2023 - Am Soc Microbiol
Getah virus (GETV) mainly causes disease in livestock and may pose an epidemic risk due
to its expanding host range and the potential of long-distance dispersal through animal …

Zoonotic mosquito-borne arboviruses: Spillover, spillback, and realistic mitigation strategies

RK Campos, SL Rossi, RB Tesh… - Science translational …, 2023 - science.org
Emerging zoonotic mosquito-borne viruses pose increasing health threats because of
growing mosquito population, geographic expansions, and control challenges. We …

EGR1 upregulation during encephalitic viral infections contributes to inflammation and cell death

CW Lehman, A Smith, J Kelly, JL Jacobs, JD Dinman… - Viruses, 2022 - mdpi.com
Early growth response 1 (EGR1) is an immediate early gene and transcription factor
previously found to be significantly upregulated in human astrocytoma cells infected with …

Inhibitors of the Structural and Nonstructural Proteins of Alphaviruses

DS Metibemu, OS Adeyinka, J Falode… - ACS Infectious …, 2024 - ACS Publications
The Alphavirus genus includes viruses that cause encephalitis due to neuroinvasion and
viruses that cause arthritis due to acute and chronic inflammation. There is no approved …