Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire
body. This sustained inflammatory state disrupts the coordinated communication between …

Abstract Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of
Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Individuals affected
by the disease gradually lose their capacity for abstract thinking, understanding …

Neurological disorders (NDs) are one of the leading causes of global death. A sustained
neuroinflammatory response has been reported to be associated with the pathogenesis of …

Summary Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic
processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 …

Background Central sensitization is an important mechanism of chronic migraine (CM) and
is related to the inflammatory response of microglia. The NOD-like receptor protein 3 …

Microglia, the resident immune cells of the central nervous system (CNS), have received
significant attention due to their critical roles in maintaining brain homeostasis and …

Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …