Molecular and cellular interactions in pathogenesis of sporadic Parkinson disease

LP Dolgacheva, VP Zinchenko… - International Journal of …, 2022 - mdpi.com
An increasing number of the population all around the world suffer from age-associated
neurodegenerative diseases including Parkinson's disease (PD). This disorder presents …

Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

J Wang, X Liu, Q Li - Frontiers in Neuroscience, 2023 - frontiersin.org
The microbiota-gut-brain axis connects the brain and the gut in a bidirectional manner. The
organism's homeostasis is disrupted during an ischemic stroke (IS). Cerebral ischemia …

Common shared pathogenic aspects of small vessels in heart and brain disease

R Moretti, M Janjusevic, AL Fluca, R Saro, G Gagno… - Biomedicines, 2022 - mdpi.com
Small-vessel disease (SVD), also known as microvascular endothelial dysfunction, is a
disorder with negative consequences for various organs such as the heart and brain …

[HTML][HTML] The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease

CMN Che Mohd Nassir, MD Che Ramli… - Life, 2024 - mdpi.com
The human microbiota constitute a very complex ecosystem of microorganisms inhabiting
both the inside and outside of our bodies, in which health maintenance and disease …

The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection

CMN Che Mohd Nassir, T Damodaran, NI Ismail… - Life, 2023 - mdpi.com
In this narrative review, we present the evidence on nucleotide-binding and oligomerization
(NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) …

Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats

Y Zhang, AM Sheikh, S Tabassum, K Iwasa, AZ Shibly… - GeroScience, 2024 - Springer
Cerebral small vessel diseases (CSVD) are neurological disorders associated with
microvessels, manifested pathologically as white matter (WM) changes and cortical …

Essential nutrients and cerebral small vessel diseases: a two-sample Mendelian randomization study

J Li, K **a, Z Wang, Y Liu, Y Tong, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Background Previous studies have suggested a potential association between nutrients and
cerebral small vessel disease (CSVD), but this association has not been fully addressed …