[HTML][HTML] Synapse pathology in Alzheimer's disease
J Griffiths, SGN Grant - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Synapse loss and damage are central features of Alzheimer's disease (AD) and contribute to
the onset and progression of its behavioural and physiological features. Here we review the …
the onset and progression of its behavioural and physiological features. Here we review the …
APOE Alleles and Diet in Brain Aging and Alzheimer's Disease
HN Yassine, CE Finch - Frontiers in aging neuroscience, 2020 - frontiersin.org
The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …
A concerted neuron–astrocyte program declines in ageing and schizophrenia
Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …
cellular terms. Here we describe a relationship between people's cortical neurons and …
Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease
Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …
Integrated proteomics to understand the role of neuritin (NRN1) as a mediator of cognitive resilience to Alzheimer's disease
C Hurst, DA Pugh, MH Abreha, DM Duong… - Molecular & Cellular …, 2023 - ASBMB
The molecular mechanisms and pathways enabling certain individuals to remain cognitively
normal despite high levels of Alzheimer's disease (AD) pathology remain incompletely …
normal despite high levels of Alzheimer's disease (AD) pathology remain incompletely …
Dendritic spines: mediators of cognitive resilience in aging and Alzheimer's disease
CK Walker, JH Herskowitz - The Neuroscientist, 2021 - journals.sagepub.com
Cognitive resilience is often defined as the ability to remain cognitively normal in the face of
insults to the brain. These insults can include disease pathology, such as plaques and …
insults to the brain. These insults can include disease pathology, such as plaques and …
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol
into 24 S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and …
into 24 S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and …
[HTML][HTML] Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy
Remodeling of synapses by microglia is essential for synaptic plasticity in the brain.
However, during neuroinflammation and neurodegenerative diseases, microglia can induce …
However, during neuroinflammation and neurodegenerative diseases, microglia can induce …
From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer's and Parkinson's diseases
Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …
Synaptic compensatory plasticity in Alzheimer's disease
The loss of excitatory synapses is known to underlie the cognitive deficits in Alzheimer's
disease (AD). Although much is known about the mechanisms underlying synaptic loss in …
disease (AD). Although much is known about the mechanisms underlying synaptic loss in …