The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

The pulsatile release of GnRH and LH secretion is essential for fertility in all mammals.
Pulses of LH occur approximately every hour in follicular-phase females and every 2 to 3 …

The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However,
despite several decades of investigation, the identity of the neuronal network generating …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …

The gonadal steroids estradiol and progesterone exert critical suppressive and stimulatory
actions upon the brain to control gonadotropin-releasing hormone (GnRH) release that …

Despite the importance of the mouse in biomedical research, the levels of circulating
gonadal steroids across the estrous cycle are not established with any temporal precision …

A subpopulation of kisspeptin neurons located in the arcuate nucleus (ARN) operate as the
GnRH pulse generator. The activity of this population of neurons can be monitored in real …

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder associated with
hyperandrogenism and anovulation. Although a spectrum disorder, many women with …

STUDY QUESTION Do hyperactive kisspeptin neurons contribute to abnormally high LH
secretion and downstream hyperandrogenemia in polycystic ovary syndrome (PCOS)-like …

Polycystic ovary syndrome (PCOS), a common reproductive disorder in women, is
characterized by hyperandrogenemia, chronic anovulation, cystic ovarian follicles, and …