Why is placentation abnormal in preeclampsia?

SJ Fisher - American journal of obstetrics and gynecology, 2015 - Elsevier
The causes of preeclampsia remain one of the great medical mysteries of our time. This
syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal …

Pre-eclampsia part 1: current understanding of its pathophysiology

T Chaiworapongsa, P Chaemsaithong, L Yeo… - Nature Reviews …, 2014 - nature.com
Pre-eclampsia is characterized by new-onset hypertension and proteinuria at≥ 20 weeks of
gestation. In the absence of proteinuria, hypertension together with evidence of systemic …

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease

CE Powe, RJ Levine, SA Karumanchi - Circulation, 2011 - Am Heart Assoc
Preeclampsia is a clinical syndrome defined as the new onset of hypertension and
proteinuria during the second half of pregnancy. 1 It afflicts 3% to 5% of pregnancies and is …

Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity

R Romero, O Erez, M Hüttemann, E Maymon… - American journal of …, 2017 - Elsevier
Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

Endothelial cells in physiology and in the pathophysiology of vascular disorders

DB Cines, ES Pollak, CA Buck… - Blood, The Journal …, 1998 - ashpublications.org
PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Preeclampsia: an endothelial cell disorder

JM Roberts, RN Taylor, TJ Musci, GM Rodgers… - American journal of …, 1989 - Elsevier
Despite intense study preeclampsia remains enigmatic and a major cause of maternal and
fetal morbidity and mortality. Most investigative efforts have focused on the hypertensive …

Genetic conflicts in human pregnancy

D Haig - The Quarterly review of biology, 1993 - journals.uchicago.edu
Pragnancy has commonly been viewed as a cooperative interaction between a mother and
her fetus. The effects of natural selection on genes expressed in fetuses, however, may be …

Pathogenesis of preeclampsia

BC Young, RJ Levine… - Annual Review of …, 2010 - annualreviews.org
Preeclampsia is a systemic syndrome that occurs in 3 to 5% of pregnant women and
classically manifests as new-onset hypertension and proteinuria after 20 weeks of gestation …

From pregnancy to preeclampsia: a key role for estrogens

N Berkane, P Liere, JP Oudinet, A Hertig… - Endocrine …, 2017 - academic.oup.com
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

Pre-eclampsia and the placenta

CWG Redman - Placenta, 1991 - Elsevier
Pre-eclampsia is a syndrome that is common, dangerous for both mother and baby,
unpredictable in its onset and progression, and untreatable except by terminating the …