On the diverse functions of electrical synapses

MJ Vaughn, JS Haas - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Electrical synapses are the neurophysiological product of gap junctional pores between
neurons that allow bidirectional flow of current between neurons. They are expressed …

Synchrony and so much more: Diverse roles for electrical synapses in neural circuits

BW Connors - Developmental Neurobiology, 2017 - Wiley Online Library
Electrical synapses are neuronal gap junctions that are ubiquitous across brain regions and
species. The biophysical properties of most electrical synapses are relatively simple …

Gap junctions desynchronize a neural circuit to stabilize insect flight

S Hürkey, N Niemeyer, JH Schleimer, S Ryglewski… - Nature, 2023 - nature.com
Insect asynchronous flight is one of the most prevalent forms of animal locomotion used by
more than 600,000 species. Despite profound insights into the motor patterns …

Connexins and pannexins: At the junction of neuro‐glial homeostasis & disease

AS Lapato, SK Tiwari‐Woodruff - Journal of neuroscience …, 2018 - Wiley Online Library
In the central nervous system (CNS), connexin (Cx) s and pannexin (Panx) s are an integral
component of homeostatic neuronal excitability and synaptic plasticity. Neuronal Cx gap …

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

M Mesnil, N Defamie, C Naus, D Sarrouilhe - Biomolecules, 2020 - mdpi.com
The incidence of brain pathologies has increased during last decades. Better diagnosis
(autism spectrum disorders) and longer life expectancy (Parkinson's disease, Alzheimer's …

Functionally distinct circuits are linked by heterocellular electrical synapses in the thalamic reticular nucleus

MJ Vaughn, Z Laswick, H Wang, JS Haas - eneuro, 2024 - eneuro.org
The thalamic reticular nucleus (TRN) inhibits sensory thalamocortical relay neurons and is a
key regulator of sensory attention as well as sleep and wake states. Recent developments …

Electrical synapses and the development of inhibitory circuits in the thalamus

TA Zolnik, BW Connors - The Journal of physiology, 2016 - Wiley Online Library
Key points The thalamus is a structure critical for information processing and transfer to the
cortex. Thalamic reticular neurons are inhibitory cells interconnected by electrical synapses …

Activity-dependent plasticity of electrical synapses: increasing evidence for its presence and functional roles in the mammalian brain

JS Haas, CM Greenwald, AE Pereda - BMC cell biology, 2016 - Springer
Gap junctions mediate electrical synaptic transmission between neurons. While the actions
of neurotransmitter modulators on the conductance of gap junctions have been extensively …

Endogenous pannexin1 channels form functional intercellular cell–cell channels with characteristic voltage-dependent properties

N Palacios-Prado, PA Soto, X López, EJ Choi… - Proceedings of the …, 2022 - pnas.org
The occurrence of intercellular channels formed by pannexin1 has been challenged for
more than a decade. Here, we provide an electrophysiological characterization of …

[HTML][HTML] Rodent somatosensory thalamocortical circuitry: Neurons, synapses, and connectivity

C O'Reilly, E Iavarone, J Yi, SL Hill - Neuroscience & Biobehavioral …, 2021 - Elsevier
As our understanding of the thalamocortical system deepens, the questions we face become
more complex. Their investigation requires the adoption of novel experimental approaches …