Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …

The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …

Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a
high mortality rate despite the decreasing incidence and new diagnostic and therapeutic …

Abstract Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …

Osteoarthritis (OA), characterized by chondrocyte apoptosis and disturbance of the balance
between catabolism and anabolism of the extracellular matrix (ECM), is the most common …

Increased risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients has
been attributed to long-standing chronic inflammation, with the contribution of genetic …

Transforming growth factor β (TGF-β) signaling is a core pathway of fibrosis, but the
molecular regulation of the activation of latent TGF-β remains incompletely understood …