Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …

Abstract In 1986, Gawin and Kleber reported a progressive increase in cue-induced drug
craving in individuals with cocaine use disorders during prolonged abstinence. After years of …

We recently developed a rat model of relapse to drug seeking after food choice-induced
voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex …

Relapse represents a consistent clinical problem for individuals with substance use
disorder. In the incubation of craving model of persistent craving and relapse, cue-induced …

Background and Purpose Studies using intermittent‐access drug self‐administration show
increased motivation to take and seek cocaine and fentanyl, relative to continuous access. In …

Studies using rodent models have shown that relapse to drug or food seeking increases
progressively during abstinence, a behavioral phenomenon termed “incubation of craving.” …

Relapse is a major problem in treating methamphetamine use disorder.“Incubation of
craving” during abstinence is a rat model for persistence of vulnerability to craving and …

Traditionally, craving is considered a defining feature of drug addiction. Accumulating
evidence suggests that craving can also exist in behavioral addictions (eg, gambling …