Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

Cirrhosis has become the major liver-related clinical endpoint in non-alcoholic
steatohepatitis (NASH). However, progression to cirrhosis is less predictable in NASH than …

Usually the dense extracellular structure in fibrotic tissues is described as extracellular
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …

Nonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not
promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

In the liver, the progressive accumulation of connective tissue, a complex and dynamic
process termed fibrosis, represents a very frequent event following a repeated or chronic …

At present chronic liver disease (CLD), the third commonest cause of premature death in the
United Kingdom is detected late, when interventions are ineffective, resulting in …

The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …