The unusual regenerative properties of the liver are a logical adaptation by organisms, as
the liver is the main detoxifying organ of the body and is likely to be injured by ingested …

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology …

The source of new hepatocytes in the uninjured liver has remained an open question. By
lineage tracing using the Wnt-responsive gene Axin2 in mice, we identify a population of …

Replicative senescence limits the proliferation of somatic cells passaged in culture and may
reflect cellular aging in vivo. The most widely used biomarker for senescent and aging cells …

The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis
and non-alcoholic fatty liver disease, with the clinical spectrum ranging in severity from …

Senescence-associated β-galactosidase is widely used as a biomarker of replicative
senescence. However, it remains unknown whether this is a distinct enzyme active at pH 6 …

The identity of cellular populations that drive liver regeneration after injury is the subject of
intense study, and the contributions of polyploid hepatocytes to organ regeneration and …

Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

Human hepatic stem cells (hHpSCs), which are pluripotent precursors of hepatoblasts and
thence of hepatocytic and biliary epithelia, are located in ductal plates in fetal livers and in …

In endoreplication cell cycles, known as endocycles, cells successively replicate their
genomes without segregating chromosomes during mitosis and thereby become polyploid …