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The physiological role of β-cell heterogeneity in pancreatic islet function
Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …
transcriptional profile, protein expression and the regulation of hormone release. Even …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
[HTML][HTML] Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes
Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …
Genetic risk converges on regulatory networks mediating early type 2 diabetes
Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is
characterized by dysfunction of insulin-producing pancreatic islet β cells1, 2. T2D genome …
characterized by dysfunction of insulin-producing pancreatic islet β cells1, 2. T2D genome …
Stomach-derived human insulin-secreting organoids restore glucose homeostasis
Gut stem cells are accessible by biopsy and propagate robustly in culture, offering an
invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in …
invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in …
The human islet: mini-organ with mega-impact
This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …
development, function, and dysfunction. After providing a historical timeline of key …
Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
[HTML][HTML] Palmitoylation couples insulin hypersecretion with β cell failure in diabetes
Hyperinsulinemia often precedes type 2 diabetes. Palmitoylation, implicated in exocytosis, is
reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic …
reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic …
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors
Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central
nervous system that also act in the pancreas as peripheral regulators of metabolism …
nervous system that also act in the pancreas as peripheral regulators of metabolism …
DYRK1A inhibitors as potential therapeutics for β-cell regeneration for diabetes
According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …