Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

The inappropriate or excessive use of antimicrobial agents caused an emerging public
health problem due to the resulting resistance developed by microbes. Therefore, there is an …

Frog skin constitutes a rich source of peptides with a wide range of biological properties.
These include host-defense peptides with cytotoxic activities against bacteria, fungi …

Cancer is the most common cause of human death worldwide. Conventional anticancer
therapies, including chemotherapy and radiation, are associated with severe side effects …

Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising
alternative source of antibiotics. Here, through structure-function-guided design, we convert …

Cationic peptides that adopt an amphipathic α-helical conformation in a membrane-mimetic
environment are synthesized in the skins of many frog species. These peptides often display …

Background With the increasing rate of antibiotic resistance in Acinetobacter, the World
Health Organization introduced the carbapenem-resistant isolates in the priority pathogens …

Cationic peptides with the propensity to adopt an amphipathic α-helical conformation in a
membrane-mimetic environment are synthesized in the skins of many species of anurans …

Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and
Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with …

The rise in antibiotic-resistant strains of clinically important pathogens is a major threat to
global health. The World Health Organization (WHO) has recognized the urgent need to …