Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Self-assembly of molecules often results in new emerging properties. Even very short
peptides can self-assemble into structures with a variety of physical and structural …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Metalloenzymes efficiently catalyze some of the most important and difficult reactions in
nature. For many years, coordination chemists have effectively used small molecule models …

While metalloprotein design has now yielded a number of successful metal-bound and even
catalytically active constructs, the question of where to put a metal site along a linear …

An important objective of de novo protein design is the preparation of metalloproteins, as
many natural systems contain metals that play crucial roles for the function and/or structural …

Conspectus The major advances in molecular and structural biology and automated peptide
and DNA synthesis of the 1970s and 1980s generated fertile conditions in the 1990s for the …