Molecular and cellular mechanisms affected in ALS
L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?
The low regeneration potential of the central nervous system (CNS) represents a challenge
for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have …
for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have …
Disease-modifying therapies in amyotrophic lateral sclerosis
A Chiò, L Mazzini, G Mora - Neuropharmacology, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of adult life, causing
weakness and wasting of voluntary muscles, associated in about 50% of cases with a …
weakness and wasting of voluntary muscles, associated in about 50% of cases with a …
Hydrogels and cell based therapies in spinal cord injury regeneration
Spinal cord injury (SCI) is a central nervous system‐(CNS‐) related disorder for which there
is yet no successful treatment. Within the past several years, cell‐based therapies have …
is yet no successful treatment. Within the past several years, cell‐based therapies have …
Brain-derived neurotrophic factor: a novel dynamically regulated therapeutic modulator in neurological disorders
The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-
related kinase receptor type B (TrkB) play an active role in numerous areas of the adult …
related kinase receptor type B (TrkB) play an active role in numerous areas of the adult …
Therapeutic utility of mesenchymal stromal cell (MSC)-based approaches in chronic neurodegeneration: a glimpse into underlying mechanisms, current status, and …
M Rahbaran, AO Zekiy, M Bahramali… - Cellular & Molecular …, 2022 - Springer
Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated
therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a …
therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a …
Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats
T Inoue, M Sugiyama, H Hattori, H Wakita… - … Engineering Part A, 2013 - liebertpub.com
Regenerative therapy using stem cells is a promising approach for the treatment of stroke.
Recently, we reported that dental pulp stem cells (DPSC) ameliorated ischemic tissue injury …
Recently, we reported that dental pulp stem cells (DPSC) ameliorated ischemic tissue injury …
Role of mesenchymal stem cells in neurogenesis and nervous system repair
DJ Maltman, SA Hardy, SA Przyborski - Neurochemistry international, 2011 - Elsevier
Bone marrow-derived mesenchymal stem cells (MSCs) are attractive candidates for use in
regenerative medicine since they are easily accessible and can be readily expanded in vivo …
regenerative medicine since they are easily accessible and can be readily expanded in vivo …
Role of BDNF in central motor structures and motor diseases
Brain-derived neurotrophic factor (BDNF), belonging to the neurotrophic family of growth
factors, has a widespread distribution in the central and peripheral nervous systems. In …
factors, has a widespread distribution in the central and peripheral nervous systems. In …