Telomeres mediate biologic aging in organisms as diverse as plants, yeast, and mammals.
We propose a telomere theory of reproductive aging that posits telomere shortening in the …

Endometrial cancers exhibit a different mechanism of tumorigenesis and progression
depending on histopathological and clinical types. The most frequently altered gene in …

Short telomeres are one of the main genetic manifestations in human cancer, as they have
been shown to play an important role in inducing chromosomal instability and in contributing …

Endometrial cancer is the most common gynecologic malignancy and the fourth most
common malignancy in women. For most patients in whom the disease is confined to the …

Endometrial cancer–the most common malignancy of the female reproductive tract–arises
from the specialized epithelial cells that line the inner surface of the uterus. Although …

Endometrial cancer (EC) is a common gynecological cancer. In some parts of the world, the
incidence and mortality of EC are on the rise. Understanding the risk factors of EC is …

STUDY QUESTION How does regulation of telomerase activity (TA) in human endometrial
epithelial cells (EEC) by ovarian hormones impact on telomere lengths (TL) and cell …

BACKGROUND Eukaryotic chromosomal ends are linear and are protected by
nucleoprotein complexes known as telomeres. The complex structural anatomy and the …

Abstract Development of personalised cancer models to predict response to radiation would
benefit patient care; particularly in malignancies where treatment resistance is prevalent …

Endometrial polyps (EMPs) are common exophytic masses associated with abnormal
uterine bleeding and infertility. Unlike normal endometrium, which is cyclically shed, EMPs …