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The sleep–circadian interface: A window into mental disorders
Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …
Magnetic field effects in biology from the perspective of the radical pair mechanism
Hundreds of studies have found that weak magnetic fields can significantly influence various
biological systems. However, the underlying mechanisms behind these phenomena remain …
biological systems. However, the underlying mechanisms behind these phenomena remain …
[HTML][HTML] Circadian rhythms and mood disorders: Time to see the light
The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …
Circadian rhythms, disease and chronotherapy
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi‐disciplinary literature review and agenda for future …
MJ McCarthy, JF Gottlieb, R Gonzalez… - Bipolar …, 2022 - Wiley Online Library
Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …
and appetite. Since many of these processes are regulated by circadian function, circadian …
Circadian biology to advance therapeutics for mood disorders
Mood disorders account for a significant global disease burden, and pharmacological
innovation is needed as existing medications are suboptimal. A wide range of evidence …
innovation is needed as existing medications are suboptimal. A wide range of evidence …
[HTML][HTML] The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells
The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented …
coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented …
[HTML][HTML] Lithium affects the circadian clock in the choroid plexus–A new role for an old mechanism
K Liška, T Dočkal, P Houdek, M Sládek, V Lužná… - Biomedicine & …, 2023 - Elsevier
Lithium is an effective mood stabilizer, but the mechanism of its therapeutic action is not well
understood. We investigated the effect of lithium on the circadian clock located in the …
understood. We investigated the effect of lithium on the circadian clock located in the …
The impact of lithium on circadian rhythms and implications for bipolar disorder pharmacotherapy
KE Rohr, MJ McCarthy - Neuroscience letters, 2022 - Elsevier
Bipolar disorder (BD) is characterized by disrupted circadian rhythms affecting sleep,
arousal, and mood. Lithium is among the most effective mood stabilizer treatments for BD …
arousal, and mood. Lithium is among the most effective mood stabilizer treatments for BD …
Reciprocal relationship between calcium signaling and circadian clocks: Implications for calcium homeostasis, clock function, and therapeutics
In animals, circadian clocks impose a daily rhythmicity to many behaviors and physiological
processes. At the molecular level, circadian rhythms are driven by intracellular …
processes. At the molecular level, circadian rhythms are driven by intracellular …