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Challenges and issues with streptozotocin-induced diabetes–a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics
Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
[HTML][HTML] Multi-organ protective effects of curcumin nanoparticles on drug-induced acute myocardial infarction in rats with type 1 Diabetes Mellitus
The objectives of this study were to investigate the cardio-protective, hepatoprotective and
nephroprotective effects of curcumin nanoparticle (NC) pretreatment compared to …
nephroprotective effects of curcumin nanoparticle (NC) pretreatment compared to …
The anatomy and physiology of the sinoatrial node—a contemporary review
The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging,
heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety …
heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety …
[HTML][HTML] Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical …
Diabetic peripheral neuropathy (DPN) is a long-term complication associated with nerve
dysfunction and uncontrolled hyperglycemia. In spite of new drug discoveries, development …
dysfunction and uncontrolled hyperglycemia. In spite of new drug discoveries, development …
Single cell RNA sequencing (scRNA-Seq) deciphering pathological alterations in streptozotocin-induced diabetic retinas
L Sun, R Wang, G Hu, H Liu, K Lv, Y Duan… - Experimental eye …, 2021 - Elsevier
Diabetic retinopathy (DR) is an irreversible and progressive diabetic complication leading to
visual impairment, even blindness. Due to the delicate and complicated structure of the …
visual impairment, even blindness. Due to the delicate and complicated structure of the …
[HTML][HTML] Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic …
Hyperglycemia and hyperlipidemia-arbitrated mitochondrial oxidative insult is key reason for
cardiac dysfunction and cardiomyopathy. Sinapic acid (SA) is a hydroxycinnamic acid (a …
cardiac dysfunction and cardiomyopathy. Sinapic acid (SA) is a hydroxycinnamic acid (a …
Diabetes regulates mitochondrial biogenesis and fission in mouse neurons
Aims/hypothesis Normal mitochondrial activity is a critical component of neuronal
metabolism and function. Disruption of mitochondrial activity by altered mitochondrial fission …
metabolism and function. Disruption of mitochondrial activity by altered mitochondrial fission …
[HTML][HTML] Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and …
The objective of our study was to evaluate the effect of Physalis peruviana L. fruits in the
management of diabetes and diabetic nephropathy in relation to its metabolic profile. In-vitro …
management of diabetes and diabetic nephropathy in relation to its metabolic profile. In-vitro …
Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway
Vascular complications are a leading cause of morbidity and mortality among diabetic
patients. This work aimed to investigate possible influences of dimethyl fumarate (DMF) on …
patients. This work aimed to investigate possible influences of dimethyl fumarate (DMF) on …