Chondrogenesis is an essential process in vertebrates. It leads to the formation of cartilage
growth plates, which drive body growth and have primary roles in endochondral ossification …

Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to
loss of joint function. The molecular mechanisms regulating pathogenesis and progression …

Cell-fate determination of pluripotent cells, cell proliferation, differentiation, and maturation,
as well as the maintenance of stem cells, are essential cellular events during …

The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-
Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains …

Sox9 encodes an essential transcriptional regulator of chondrocyte specification and
differentiation. When Sox9 nuclear activity was compared with markers of chromatin …

Vertebrate skeletogenesis consists in elaborating an edifice of more than 200 pieces of
bone and cartilage. Each skeletal piece is crafted at a distinct location in the body, is …

In mammals, male sex is determined by the Y-chromosomal gene Sry (sex-determining
region of Y chromosome). The expression of Sry and subsequently Sox9 (SRY box …

Since the discovery of SOX9 mutations in the severe human skeletal malformation syndrome
campomelic dysplasia in 1994, Sox9 was shown to be both required and sufficient for …

Tris (1, 3-dichloro-2-propyl) phosphate (TDCPP) is frequently present in indoor dust and can
be detected in human milk. In order to evaluate the effects of TDCPP on vertebrate …

The matrilins form a family of oligomeric extracellular adaptor proteins that are most strongly
expressed in cartilage but also present in many other extracellular matrices. Matrilins bind to …