Engineered peptide modified hydrogel platform for propagation of human pluripotent stem cells

T Richardson, C Wiegand, F Adisa, K Ravikumar… - Acta Biomaterialia, 2020 - Elsevier
Human pluripotent stem cells (hPSCs) have enormous potential to alleviate cell needs for
regenerative medicine, however these cells require expansion in cell colonies to maintain …

Multiwell combinatorial hydrogel array for high-throughput analysis of cell–ECM Interactions

R Lei, EA Akins, KCY Wong, NA Repina… - ACS biomaterials …, 2021 - ACS Publications
Biophysical cues in the extracellular matrix (ECM) regulate cell behavior in a complex,
nonlinear, and interdependent manner. To quantify these important regulatory relationships …

Stress-free Bioprinting of Human Primary and iPSC-derived Islets with Retained Functionality

M Poklar, RK, C Wiegand, B Mizerak, R Wang… - bioRxiv, 2024 - biorxiv.org
Currently, Type 1 diabetes (T1D) can be treated through implantation of allogenic islets,
which replenish the beta cell population, however this method requires an extensive post …

Pancreatic Islet Microphysiology System for Disease Modeling of Type 2 Diabetes

CR Wiegand - 2023 - search.proquest.com
Diabetes has become an increasingly prominent global issue afflicting 10% of world's
population where type 2 diabetes (T2D) comprises the majority of those diagnosed. T2D …

Engineering Biophysical Cues for Controlled 3D Differentiation of Endoderm Derivatives

T Richardson, S Mathew, C Wiegand, K Pietz… - … : Methods and Protocols, 2021 - Springer
Biophysical cues synergize with biochemical cues to drive differentiation of pluripotent stem
cells through specific phenotypic trajectory. Tools to manipulate the cell biophysical …