Oral squamous cell carcinomas: state of the field and emerging directions

Y Tan, Z Wang, M Xu, B Li, Z Huang, S Qin… - International journal of …, 2023 - nature.com
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Intratumoural microbiota: a new frontier in cancer development and therapy

Y Cao, H **a, X Tan, C Shi, Y Ma, D Meng… - … and Targeted Therapy, 2024 - nature.com
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several
physiological and pathological processes. Some studies discovered that tumour tissues …

Clinical update on head and neck cancer: molecular biology and ongoing challenges

E Alsahafi, K Begg, I Amelio, N Raulf, P Lucarelli… - Cell death & …, 2019 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Microbiota in tumors: from understanding to application

Y **e, F **e, X Zhou, L Zhang, B Yang… - Advanced …, 2022 - Wiley Online Library
Microbes with complex functions have been found to be a potential component in tumor
microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is …

Role of oral microbiome signatures in diagnosis and prognosis of oral cancer

I Chattopadhyay, M Verma… - Technology in cancer …, 2019 - journals.sagepub.com
Despite advancement in cancer treatment, oral cancer has a poor prognosis and is often
detected at late stage. To overcome these challenges, investigators should search for early …

The oral microbiome and cancer

M Irfan, RZR Delgado, J Frias-Lopez - Frontiers in immunology, 2020 - frontiersin.org
There is mounting evidence that members of the human microbiome are highly associated
with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma …

Variations in oral microbiota associated with oral cancer

H Zhao, M Chu, Z Huang, X Yang, S Ran, B Hu… - Scientific reports, 2017 - nature.com
Individual bacteria and shifts in microbiome composition are associated with human
disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis …

Intratumor microbiome in cancer progression: current developments, challenges and future trends

J Liu, Y Zhang - Biomarker Research, 2022 - Springer
Cancer is a complicated disease attributed to multifactorial changes, which causes
difficulties with treatment strategies. Various factors have been regarded as the main …

Microbiota dysbiosis in select human cancers: evidence of association and causality

J Chen, JC Domingue, CL Sears - Seminars in immunology, 2017 - Elsevier
The human microbiota is a complex ecosystem of diverse microorganisms consisting of
bacteria, viruses, and fungi residing predominantly in epidermal and mucosal habitats …

Dysbiosis of salivary microbiome and cytokines influence oral squamous cell carcinoma through inflammation

AK Rai, M Panda, AK Das, T Rahman, R Das… - Archives of …, 2021 - Springer
Advanced combinatorial treatments of surgery, chemotherapy, and radiotherapy do not have
any effect on the enhancement of a 5-year survival rate of oral squamous cell carcinoma …