Redox signaling and metabolism in Alzheimer's disease

MI Holubiec, M Gellert… - Frontiers in aging …, 2022 - frontiersin.org
Reduction and oxidation reactions are essential for biochemical processes. They are part of
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …

Resveratrol mediated regulation of hippocampal neuroregenerative plasticity via SIRT1 pathway in synergy with Wnt signaling: Neurotherapeutic implications to …

K Surya, N Manickam… - Journal of …, 2023 - journals.sagepub.com
Alzheimer's disease (AD) is a major form of dementia. Abnormal amyloidogenic event-
mediated degeneration of cholinergic neurons in the cognitive centers of the brain has been …

GSK3: A potential target and pending issues for treatment of Alzheimer's disease

J Zhao, M Wei, M Guo, M Wang, H Niu… - CNS Neuroscience & …, 2024 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3), consisting of GSK3α and GSK3β subtypes, is
a complex protein kinase that regulates numerous substrates. Research has observed …

Study on the mechanism for SIRT1 during the process of exercise improving depression

X Qiu, P Lu, X Zeng, S **, X Chen - Brain sciences, 2023 - mdpi.com
The mechanism behind the onset of depression has been the focus of current research in
the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating …

[HTML][HTML] In vivo and computational studies on sitagliptin's neuroprotective role in type 2 diabetes mellitus: implications for Alzheimer's disease

V Mani, M Arfeen - Brain Sciences, 2024 - mdpi.com
Background/Objectives: Diabetes mellitus (DM), a widespread endocrine disorder
characterized by chronic hyperglycemia, can cause nerve damage and increase the risk of …

[HTML][HTML] Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease

D Chen, J Huang, S Su, Q Chen, B Wu - Regenerative Therapy, 2024 - Elsevier
Cerebral small vessel disease (CSVD), as the most common, chronic and progressive
vascular disease on the brain, is a serious neurological disease, whose pathogenesis …

Systems medicine as a strategy to deal with Alzheimer's disease

XX Zeng, JB Zeng - Journal of Alzheimer's Disease, 2023 - journals.sagepub.com
The traits of Alzheimer's disease (AD) include amyloid plaques made of Aβ1-40 and Aβ1-42,
and neurofibrillary tangles by the hyperphosphorylation of tau protein. AD is a complex …

Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs

M Aschner, AV Skalny, A Santamaria, JBT Rocha… - Neurochemical …, 2024 - Springer
Aluminum (Al) is known to induce neurotoxic effects, potentially contributing to Alzheimer's
disease (AD) pathogenesis. Recent studies suggest that epigenetic modification may …

Interaction between resveratrol and SIRT1: role in neurodegenerative diseases

L Zhu, M Yang, L Fan, Q Yan, L Zhang, P Mu… - Naunyn-Schmiedeberg's …, 2024 - Springer
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and
Huntington's disease, pose significant health challenges and economic burdens worldwide …

The GLP-1 Agonist Semaglutide Ameliorates Cognitive Regression in P301S Tauopathy Mice Model via Autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia …

NN Elbadawy, MA Saad, S Elfarrash… - European Journal of …, 2025 - Elsevier
Tau hyper-phosphorylation has been recognized as an essential contributor to
neurodegeneration in Alzheimer's disease (AD) and related tauopathies. In the last decade …