Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Asymmetric synthesis of isoquinoline alkaloids: 2004–2015

M Chrzanowska, A Grajewska… - Chemical …, 2016 - ACS Publications
In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a
family of natural products showing a wide range of structural diversity and biological and …

Building bridges: Biocatalytic C–C-bond formation toward multifunctional products

NG Schmidt, E Eger, W Kroutil - ACS catalysis, 2016 - ACS Publications
Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

Flavoprotein oxidases: classification and applications

WP Dijkman, G de Gonzalo, A Mattevi… - Applied Microbiology and …, 2013 - Springer
This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This
class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically …

[HTML][HTML] Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

M Müller, S Gerndt, YK Chao, T Zisis, ONP Nguyen… - Cell chemical …, 2021 - cell.com
The role of two-pore channel 2 (TPC2), one of the few cation channels localized on
endolysosomal membranes, in cancer remains poorly understood. Here, we report that …

Biocatalytic Methods for C C Bond Formation

K Fesko, M Gruber‐Khadjawi - ChemCatChem, 2013 - Wiley Online Library
Carbon‐carbon bond formation is among the most challenging transformations in the
organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest …

Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

W Kroutil, EM Fischereder, CS Fuchs… - … process research & …, 2013 - ACS Publications
This account focuses on the application of ω-transaminases, lyases, and oxidases for the
preparation of amines considering mainly work from our own lab. Examples are given to …

Oxidation of monolignols by members of the berberine bridge enzyme family suggests a role in plant cell wall metabolism

B Daniel, T Pavkov-Keller, B Steiner, A Dordic… - Journal of Biological …, 2015 - ASBMB
Plant genomes contain a large number of genes encoding for berberine bridge enzyme
(BBE)-like enzymes. Despite the widespread occurrence and abundance of this protein …

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

BR Lichman, ED Lamming, T Pesnot, JM Smith… - Green …, 2015 - pubs.rsc.org
We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-
tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and …

Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology

XL Li, YP Sun, M Wang, ZB Wang… - Frontiers in …, 2024 - frontiersin.org
Chelidonium majus L.(C. majus), commonly known as “Bai Qu Cai” in China, belongs to the
genus Chelidonium of the Papaveraceae family. It has rich medicinal value, such as …