Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

ABCB1, also known as P-glycoprotein, actively extrudes xenobiotic compounds across the
plasma membrane of diverse cells, which contributes to cellular drug resistance and …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug
disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule …

ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in
the plasma membrane in cells of various tissues and tissue barriers, including the blood …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …