How autophagy controls the intestinal epithelial barrier
EG Foerster, T Mukherjee, L Cabral-Fernandes… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …
mediated recycling of organelles and protein aggregates, as well as the destruction of …
Progress in therapies for cystic fibrosis
K De Boeck, MD Amaral - The Lancet Respiratory Medicine, 2016 - thelancet.com
Standard follow-up and symptomatic treatment have allowed most patients with cystic
fibrosis to live to young adulthood. However, many patients still die prematurely from …
fibrosis to live to young adulthood. However, many patients still die prematurely from …
Secretory autophagy
Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less
intuitive but biologically distinct non-degradative roles. One manifestation of these functions …
intuitive but biologically distinct non-degradative roles. One manifestation of these functions …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
Autophagy is required for memory formation and reverses age-related memory decline
M Glatigny, S Moriceau, M Rivagorda… - Current Biology, 2019 - cell.com
Age-related declines in cognitive fitness are associated with a reduction in autophagy, an
intracellular lysosomal catabolic process that regulates protein homeostasis and organelle …
intracellular lysosomal catabolic process that regulates protein homeostasis and organelle …
Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis
N Vij, P Chandramani-Shivalingappa… - … of Physiology-Cell …, 2018 - journals.physiology.org
Cigarette-smoke (CS) exposure and aging are the leading causes of chronic obstructive
pulmonary disease (COPD)-emphysema development, although the molecular mechanism …
pulmonary disease (COPD)-emphysema development, although the molecular mechanism …
Cystic fibrosis: a clinical view
C Castellani, BM Assael - Cellular and molecular life sciences, 2017 - Springer
Cystic fibrosis (CF), a monogenic disease caused by mutations in the CFTR gene on
chromosome 7, is complex and greatly variable in clinical expression. Airways, pancreas …
chromosome 7, is complex and greatly variable in clinical expression. Airways, pancreas …
CFTR modulators: shedding light on precision medicine for cystic fibrosis
M Lopes-Pacheco - Frontiers in pharmacology, 2016 - frontiersin.org
Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …
Autophagy: a druggable process that is deregulated in aging and human disease
G Kroemer - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Autophagy (“self-eating”) constitutes one of the most spectacular yet subtly regulated
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …
Epigallocatechin-3-gallate therapeutic potential in cancer: mechanism of action and clinical implications
Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …
proliferation and apoptosis have emerged as rational targets that can be exploited in the …