Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008
Isatin (1H-indole-2, 3-dione) and its derivatives demonstrate a diverse array of biological
and pharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral …
and pharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral …
Advances in pharmacology of isatin and its derivatives: A review
Abstract Isatin (1H-indole-2, 3-dione), an indole derivative of plant origin, is involved in many
pharmacological activities like antiallergic, antimalarial, antiviral and antimicrobial; isatin …
pharmacological activities like antiallergic, antimalarial, antiviral and antimicrobial; isatin …
QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent
Isatin is an important compound from the biological aspect of view. It is an endogenous
substance and moreover; various pharmacological activities have been reported for isatin …
substance and moreover; various pharmacological activities have been reported for isatin …
Bioassays for anticancer activities
J McCauley, A Zivanovic, D Skropeta - Metabolomics tools for natural …, 2013 - Springer
The MTT/MTS in vitro cell proliferation assay is one of the most widely used assays for
evaluating preliminary anticancer activity of both synthetic derivatives and natural products …
evaluating preliminary anticancer activity of both synthetic derivatives and natural products …
Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells
Abstract Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone
derivatives have been synthesized and their structural and biological characteristics have …
derivatives have been synthesized and their structural and biological characteristics have …
Novel hydrazone‐isatin derivatives as potential EGFR inhibitors: Synthesis and in vitro pharmacological profiling
Merging isatin and arylhydrazone moieties constitutes an efficient strategy to access new
potential anticancer derivatives. Consequently, 14 hydrazone‐isatin derivatives were …
potential anticancer derivatives. Consequently, 14 hydrazone‐isatin derivatives were …
A series of isatin-hydrazones with cytotoxic activity and CDK2 kinase inhibitory activity: a potential type II ATP competitive inhibitor
Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …
Antioxidant & anticancer activities of isatin (1H-indole-2, 3-dione), isolated from the flowers of Couroupita guianensis Aubl
M Premanathan, S Radhakrishnan… - Indian Journal of …, 2012 - journals.lww.com
Methods: Active fractions demonstrating anticancer and antioxidant activities were isolated
from the extracts of shade-dried flowers of C. guianensis by bioassay guided fractionation …
from the extracts of shade-dried flowers of C. guianensis by bioassay guided fractionation …
Preparation, characterization, antioxidant properties of novel Schiff bases including 5-chloroisatin-thiocarbohydrazone
TK Bakır, JB Lawag - Research on Chemical Intermediates, 2020 - Springer
Thanks to its pharmaceutical properties, the Schiff group of isatin has recently had a wide
range of uses. In this study, seven new Schiff bases of isatin and its derivatives were …
range of uses. In this study, seven new Schiff bases of isatin and its derivatives were …
Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids
New isatin-triazole based hybrids have been synthesized and evaluated for their inhibitory
activity of TNF-α induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the …
activity of TNF-α induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the …