Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …

Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Defining protein–protein interactions (PPIs) in their native environment is crucial to
understanding protein structure and function. Cross-linking–mass spectrometry (XL-MS) has …

A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

We describe optimized fragmentation schemes and data analysis strategies substantially
enhancing the depth and accuracy in identifying protein cross-links using non-restricted …

In recent years, chemical crosslinking of protein complexes and the identification of
crosslinked residues by mass spectrometry (XL-MS; sometimes abbreviated as CX-MS) has …

Protein–protein interactions are fundamental to various aspects of cell biology with many
protein complexes participating in numerous fundamental biological processes such as …

Chemical cross-linking in combination with mass spectrometric analysis of the created cross-
linked products is an emerging technology aimed at deriving valuable structural information …