The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …

The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and
fidelity of the major events of the cell cycle. These include growth to the appropriate cell size …

Summary The CyclinB1-Cdk1 kinase is the catalytic activity at the heart of mitosis-promoting
factor (MPF), yet fundamental questions concerning its role in mitosis remained unresolved …

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all
chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as …

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or
senescence is often triggered after mitotic exit. To characterize this process, we conducted …

Mitotic cells inactivate DNA double-strand break (DSB) repair, but the rationale behind this
suppression remains unknown. Here, we unravel how mitosis blocks DSB repair and …

Post-translational modification (PTM) of proteins plays an important part in mediating protein
interactions and/or the recruitment of specific protein targets,. PTM can be mediated by the …

The signaling cascade initiated in response to DNA double-strand breaks (DSBs) has been
extensively investigated in interphase cells. Here, we show that mitotic cells treated with …

The Ki-67 protein is a nuclear and nucleolar protein, which is tightly associated with somatic
cell proliferation. Antibodies raised against the human Ki-67 protein paved the way for the …